Bishop Mar George Madathikandathil, son of Mathew and Aleykutty, was born on May 9, 1956. He hails from the parish of St. Sebastian's, Purapuzha, of the Eparchy of Kothamangalam. he joined the St. Joseph's Minor Seminary, Kothamangalam on July 5, 1971. he was sent to St. Joseph's Pontifical Seminary, Carmelgiri, Alwaye for his philosophical training and completed his theological training at St. Joseph's Pontifical Seminary, Mangalapuzha, Alwaye. Bishop Mar George Punnakottil ordained him priest on December 23, 1980. in 1989 he secured from the Oriental Institute in Rome his Doctorate in Canon Law on the subject: "The Catholic Bishops' Conference of India (CBCI): An Inter-ecclesial Assembly".

He served as professor in St. Thomas Apostolic Seminary, Vadavathoor, Kottayam. He served the seminary as professor, Vice-Rector and Rector for a long span of 17 years. Bishop Mar George Madathikandathil was enthroned on February 9, 2013 as the third bishop of the Eparchy of Kothamangalam. He now serves as the Member of the Syro-Malabar Synodal Commission for St. Joseph's Pontifical Seminary Mangalapuzha.